Type I Interferons Interfere with Liver Glucose Metabolism

Cell Metab. 2017 Jun 6;25(6):1211-1212. doi: 10.1016/j.cmet.2017.05.009.


The specific immunological components linking metabolic stresses to liver inflammation and systemic metabolic pathologies in obesity are not entirely known. A recent study (Ghazarian et al., 2017) reveals that obesity-induced type I interferon signaling drives the accumulation and activation of intrahepatic CD8+ T cells, leading to systemic metabolic deterioration.

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