Type I Interferons Interfere with Liver Glucose Metabolism

Güneş Parlakgul; Gökhan S Hotamisligil

doi:10.1016/j.cmet.2017.05.009

Type I Interferons Interfere with Liver Glucose Metabolism

Cell Metab. 2017 Jun 6;25(6):1211-1212. doi: 10.1016/j.cmet.2017.05.009.

Authors

Güneş Parlakgul¹, Gökhan S Hotamisligil²

Affiliations

¹ Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
² Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: ghotamis@hsph.harvard.edu.

PMID: 28591628
DOI: 10.1016/j.cmet.2017.05.009

Abstract

The specific immunological components linking metabolic stresses to liver inflammation and systemic metabolic pathologies in obesity are not entirely known. A recent study (Ghazarian et al., 2017) reveals that obesity-induced type I interferon signaling drives the accumulation and activation of intrahepatic CD8⁺ T cells, leading to systemic metabolic deterioration.

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