Gut-Brain Glucose Signaling in Energy Homeostasis

Cell Metab. 2017 Jun 6;25(6):1231-1242. doi: 10.1016/j.cmet.2017.04.032.


Intestinal gluconeogenesis is a recently identified function influencing energy homeostasis. Intestinal gluconeogenesis induced by specific nutrients releases glucose, which is sensed by the nervous system surrounding the portal vein. This initiates a signal positively influencing parameters involved in glucose control and energy management controlled by the brain. This knowledge has extended our vision of the gut-brain axis, classically ascribed to gastrointestinal hormones. Our work raises several questions relating to the conditions under which intestinal gluconeogenesis proceeds and may provide its metabolic benefits. It also leads to questions on the advantage conferred by its conservation through a process of natural selection.

Keywords: brain glucose sensing; endogenous glucose production; energy homeostasis; food intake; glucose control; insulin sensitivity; intestinal gluconeogenesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / metabolism*
  • Energy Metabolism / physiology*
  • Gastrointestinal Hormones / metabolism*
  • Glucose / metabolism*
  • Humans
  • Intestinal Mucosa / metabolism*
  • Signal Transduction / physiology*


  • Gastrointestinal Hormones
  • Glucose