Neural Sources and Underlying Mechanisms of Neural Responses to Heartbeats, and their Role in Bodily Self-consciousness: An Intracranial EEG Study

Cereb Cortex. 2018 Jul 1;28(7):2351-2364. doi: 10.1093/cercor/bhx136.


Recent research has shown that heartbeat-evoked potentials (HEPs), brain activity in response to heartbeats, are a useful neural measure for investigating the functional role of brain-body interactions in cognitive processes including self-consciousness. In 2 experiments, using intracranial electroencephalography (EEG), we investigated (1) the neural sources of HEPs, (2) the underlying mechanisms for HEP generation, and (3) the functional role of HEPs in bodily self-consciousness. In Experiment-1, we found that shortly after the heartbeat onset, phase distributions across single trials were significantly concentrated in 10% of the recording sites, mainly in the insula and the operculum, but also in other regions including the amygdala and fronto-temporal cortex. Such phase concentration was not accompanied by increased spectral power, and did not correlate with spectral power changes, suggesting that a phase resetting, rather than an additive "evoked potential" mechanism, underlies HEP generation. In Experiment-2, we further aimed to anatomically refine previous scalp EEG data that linked HEPs with bodily self-consciousness. We found that HEP modulations in the insula reflected an experimentally induced altered sense of self-identification. Collectively, these results provide novel and solid electrophysiological evidence on the neural sources and underlying mechanisms of HEPs, and their functional role in self-consciousness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Pressure / physiology
  • Brain Mapping*
  • Consciousness / physiology*
  • Electrocorticography
  • Electroencephalography
  • Epilepsy / diagnostic imaging
  • Epilepsy / pathology
  • Epilepsy / physiopathology
  • Evoked Potentials / physiology*
  • Female
  • Heart Rate / physiology*
  • Humans
  • Imagination
  • Interoception / physiology*
  • Male
  • Neurons / physiology*
  • Tomography Scanners, X-Ray Computed
  • User-Computer Interface
  • Young Adult