Current and future therapies for advanced pancreatic cancer

J Surg Oncol. 2017 Jul;116(1):25-34. doi: 10.1002/jso.24623. Epub 2017 Jun 7.

Abstract

Pancreatic cancer remains a deadly disease with a 5-year survival rate of only 8%. Even after surgical resection, most patients have recurrence of their cancer. Over the last 10 years, improvements in chemotherapy regimens led to a doubling in median overall survival. Here we review the management of advanced pancreatic cancer and highlight vaccine therapy as a novel modality of treatment.

Keywords: cytotoxic chemotherapy; pancreas cancer; vaccine therapy.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / analysis
  • CA-19-9 Antigen / analysis
  • Cancer Pain / therapy
  • Chemotherapy, Adjuvant
  • Clinical Trials as Topic
  • Genetic Predisposition to Disease
  • Humans
  • Neoadjuvant Therapy
  • Neoplasm Staging
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / mortality
  • Pancreatic Neoplasms / pathology
  • Pancreatic Neoplasms / therapy*
  • Risk Factors

Substances

  • Biomarkers, Tumor
  • CA-19-9 Antigen