Objective: To study the value of Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea in older inpatients. Methods: A total of 163 older patients who were treated with wide-spectrum antibiotics at least three days during January 2014 to December 2015 were randomly divided into control and study group. In study group, 81 patients were administrated with oral Saccharomyces boulardii 500 mg twice a day for 21 days. The control group was of no intervention. Morbidity rate of antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea, frequency and duration of diarrhea were recorded. Results: The incidence of antibiotic-associated diarrhea in study group was significantly lower than that in control group [14.8%(12/81) vs 28.0%(23/82), P<0.05], whereas no difference was seen in the incidence of Clostridium difficile-associated diarrhea [3.7%(3/81) vs 4.9%(4/82), P>0.05] in two groups. The frequency and duration of diarrhea in the study group were significantly lower and shorter than those in control group[(4.3±1.7) times/day vs (6.9±2.0) times/day; (3.0±1.1) days vs (5.7±1.8) days, both P<0.01]. Conclusion:Saccharomyces boulardii may reduce the incidence of antibiotic-associated diarrhea therefore improving the symptom of diarrhea in older inpatients.
目的： 研究布拉酵母菌对医院内老年人抗生素相关性腹泻(AAD)的预防作用。 方法： 2014年1月至2015年12月南京军区福州总医院住院拟使用广谱抗菌药物3 d以上的老年患者163例，以随机数字表法分为两组，对照组82例，预防组81例。预防组在使用抗菌药物的同时给予布拉酵母菌500 mg/次，2次/d，连续服用21 d；对照组不予干预，作为空白对照。观察12周内AAD和艰难梭菌相关性腹泻的发生情况以及腹泻的次数、持续时间。 结果： 预防组AAD发生率明显低于对照组[14.8%(12/81)比28.0%(23/82)，P<0.05]，而艰难梭菌相关性腹泻发生率两组间差异无统计学意义[3.7%(3/81)比4.9%(4/82)，P>0.05]；此外，预防组的腹泻次数及持续时间明显少于对照组[(4.3±1.7)次/d比(6.9±2.0)次/d；(3.0±1.1)d比(5.7±1.8)d，P值均<0.01]。 结论： 布拉酵母菌可以预防住院老年患者AAD的发生，减轻AAD和艰难梭菌相关性腹泻的腹泻症状，促进腹泻症状的好转。.
Keywords: Aged; Antibiotic-associated diarrhea; Prevention; Saccharomyces boulardii.