Rheumatoid arthritis: Forward and reverse inheritance - the yin and the yang

Nat Rev Rheumatol. 2017 Jul;13(7):396-397. doi: 10.1038/nrrheum.2017.88. Epub 2017 Jun 8.


The theory of Mendelian inheritance states that half our genes are maternal and half are paternal. This view is incomplete, as maternal–fetal exchange creates a legacy of non-native cells within an individual that can affect their health for better or worse, including contributing to their risk of developing autoimmune disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Alleles
  • Arthritis, Rheumatoid*
  • Child
  • Female
  • Humans
  • Mothers*