The Effect of Dietary Supplements Containing Green Tea, Capsaicin and Ginger Extracts on Weight Loss and Metabolic Profiles in Overweight Women: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Ann Nutr Metab. 2017;70(4):277-285. doi: 10.1159/000471889. Epub 2017 Jun 9.

Abstract

Background: This study was conducted to determine the effects of dietary supplements containing green tea, capsaicin and ginger extracts on weight loss and metabolic profiles among overweight women.

Methods: This randomized double-blind placebo-controlled clinical trial was implemented among 50 overweight women. Participants were randomly divided into 2 groups. Group A received dietary supplements containing 125 mg green tea, 25 mg capsaicin and 50 mg ginger extracts (n = 25) group B received placebos (n = 25) twice with lunch and twice with dinner daily for 8 weeks.

Results: Compared with placebo, taking dietary supplements containing green tea, capsaicin and ginger resulted in a significant decrease in weight (-1.8 ± 1.5 vs. +0.4 ± 1.2 kg, respectively, p < 0.001) and body mass index (BMI; -0.7 ± 0.5 vs. +0.1 ± 0.5 kg/m2, respectively, p < 0.001). In addition, subjects who received green tea, capsaicin and ginger co-supplements had significantly decreased serum insulin concentrations (-2.6 ± 3.9 vs. -0.6 ± 2.0 µIU/mL, p = 0.02), homeostatic model of assessment for insulin resistance (-0.5 ± 0.8 vs. -0.05 ± 0.6, p = 0.01), and increased quantitative insulin sensitivity check index (+0.01 ± 0.01 vs. +0.001 ± 0.01, p = 0.008) and plasma glutathione (GSH) levels (+73.8 ± 120.6 vs. -28.3 ± 193.4 µmol/L, p = 0.03) compared with the placebo.

Conclusions: Our study indicated that taking green tea, capsaicin and ginger co-supplements for 8 weeks among overweight women had beneficial effects on weight, BMI, markers of insulin metabolism and plasma GSH levels.

Keywords: Dietary supplements; Insulin resistance; Overweight; Weight loss.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Blood Glucose / metabolism
  • Body Mass Index
  • Capsaicin / pharmacology*
  • Cholesterol / blood
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Ginger / chemistry*
  • Glutathione / blood
  • Humans
  • Insulin / blood
  • Insulin Resistance
  • Iran
  • Metabolome*
  • Overweight / drug therapy*
  • Patient Compliance
  • Plant Extracts / pharmacology*
  • Tea / chemistry*
  • Treatment Outcome
  • Triglycerides / blood
  • Weight Loss / drug effects*

Substances

  • Biomarkers
  • Blood Glucose
  • Insulin
  • Plant Extracts
  • Tea
  • Triglycerides
  • Cholesterol
  • Glutathione
  • Capsaicin

Associated data

  • IRCT/IRCT2015122712438N15