Delta-sleep inducing peptide in cerebrospinal fluid from schizophrenics, depressives and healthy volunteers

Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(1):83-90. doi: 10.1016/0278-5846(85)90182-4.

Abstract

CSF levels of DSIP was measured in healthy volunteers and in hospitalized patients with schizophrenia or major depressive disorders. Both patient groups had significantly lower CSF levels of DSIP than the healthy volunteers. There was a tendency for lower CSF levels of DSIP in female compared to male schizophrenics. Neuroleptic treatment did not significantly affect those levels. The levels of DSIP in CSF tended to be inversely correlated to the sleep disturbancy scores in the depressed patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antipsychotic Agents / pharmacology
  • Delta Sleep-Inducing Peptide
  • Depressive Disorder / cerebrospinal fluid*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oligopeptides / cerebrospinal fluid*
  • Schizophrenia / cerebrospinal fluid*
  • Schizophrenia / drug therapy
  • Sex Factors
  • Sleep / physiology

Substances

  • Antipsychotic Agents
  • Oligopeptides
  • Delta Sleep-Inducing Peptide