Three new flavanoids from artificially induced dragon's blood of Dracaena cambodiana

Fei-Xiang Li; Hui Wang; Cui-Juan Gai; Hui-Qin Chen; Wei Li; Wen-Li Mei; Hao-Fu Dai

doi:10.1080/10286020.2017.1322583

Three new flavanoids from artificially induced dragon's blood of Dracaena cambodiana

J Asian Nat Prod Res. 2018 Jan;20(1):55-61. doi: 10.1080/10286020.2017.1322583. Epub 2017 Jun 9.

Authors

Fei-Xiang Li¹, Hui Wang¹, Cui-Juan Gai¹, Hui-Qin Chen¹, Wei Li¹, Wen-Li Mei¹, Hao-Fu Dai¹

Affiliation

¹ a Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture , Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences , Haikou 571101 , China.

PMID: 28597686
DOI: 10.1080/10286020.2017.1322583

Abstract

Three new flavanoids, (2R)-7,4'-dihydroxy-8-methylflavan (1), (2R)-7,4'-dihydroxy-6-methylflavan (2), and (3R)-7,3',4'-trihydroxyhomoisoflavan (3), together with seven known compounds (4-10), were isolated from artificially induced dragon's blood of Dracaena cambodiana, and their structures were determined based on HR-ESI-MS and extensive spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 2 exhibited weak cytotoxicity against BEL-7402 cells line with the IC₅₀ value of 39.2 μM. In addition, compound 3 showed significant acetylcholinesterase (AChE) inhibitory activity.

Keywords: AChE; Artificially induced dragon’s blood; Dracaena cambodiana; cytotoxicity; flavanoids.

MeSH terms

Cholinesterase Inhibitors / chemistry
Cholinesterase Inhibitors / isolation & purification*
Cholinesterase Inhibitors / pharmacology*
Dracaena / chemistry*
Flavonoids / chemistry
Flavonoids / isolation & purification*
Flavonoids / pharmacology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Extracts / chemistry

Substances

Cholinesterase Inhibitors
Flavonoids
Plant Extracts
dragon's blood