Effect of Ursolic Acid on Metabolic Syndrome, Insulin Sensitivity, and Inflammation

J Med Food. 2017 Sep;20(9):882-886. doi: 10.1089/jmf.2017.0003. Epub 2017 Jun 9.

Abstract

To evaluate the effect of ursolic acid on metabolic syndrome, insulin sensitivity, and inflammation, a randomized, double-blind, placebo-controlled clinical trial was carried out in 24 patients (30-60 years) with a diagnosis of metabolic syndrome without treatment. They were randomly assigned to two groups of 12 patients, each to receive orally 150 mg of ursolic acid or homologated placebo once a day for 12 weeks. Before and after the intervention, the components of metabolic syndrome, insulin sensitivity (Matsuda index), and inflammation profile (interleukin-6 and C-reactive protein) were evaluated. After ursolic acid administration, the remission of metabolic syndrome occurred in 50% of patients (P = .005) with significant differences in body weight (75.7 ± 11.5 vs. 71 ± 11 kg, P = .002), body mass index (BMI) (29.9 + 3.6 vs. 24.9 ± 1.2 kg/m2, P = .049), waist circumference (93 ± 8.9 vs. 83 + 8.6 cm, P = .008), fasting glucose (6.0 ± 0.5 vs. 4.7 ± 0.4 mmol/L, P = .002), and insulin sensitivity (3.1 ± 1.1 vs. 4.2 ± 1.2, P = .003). Ursolic acid administration leads to transient remission of metabolic syndrome, reducing body weight, BMI, waist circumference and fasting glucose, as well as increasing insulin sensitivity.

Keywords: inflammation; insulin sensitivity; metabolic syndrome; ursolic acid.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Blood Glucose / metabolism
  • C-Reactive Protein / genetics
  • C-Reactive Protein / metabolism
  • Double-Blind Method
  • Female
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / genetics
  • Inflammation / metabolism
  • Inflammation / physiopathology
  • Insulin / metabolism
  • Insulin Resistance*
  • Interleukin-6 / genetics
  • Interleukin-6 / metabolism
  • Male
  • Metabolic Syndrome / drug therapy*
  • Metabolic Syndrome / metabolism
  • Metabolic Syndrome / physiopathology
  • Middle Aged
  • Triterpenes / administration & dosage*
  • Waist Circumference

Substances

  • Blood Glucose
  • Insulin
  • Interleukin-6
  • Triterpenes
  • C-Reactive Protein
  • ursolic acid