Reoperation for Recurrent Glioblastoma Multiforme

Adam M Robin; Ian Lee; Steven N Kalkanis

doi:10.1016/j.nec.2017.02.007

Reoperation for Recurrent Glioblastoma Multiforme

Neurosurg Clin N Am. 2017 Jul;28(3):407-428. doi: 10.1016/j.nec.2017.02.007.

Authors

Adam M Robin¹, Ian Lee², Steven N Kalkanis³

Affiliations

¹ Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.
² Department of Neurosurgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
³ Department of Neurosurgery, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA. Electronic address: Skalkan1@hfhs.org.

PMID: 28600015
DOI: 10.1016/j.nec.2017.02.007

Abstract

The role of reoperation for glioblastoma multiforme (GBM) recurrence is currently unknown. However, multiple studies have indicated that survival and quality of life are improved with a repeat operation at the time of disease recurrence. Prognosis is likely interdependent on several factors, including age, functional status, initial resection status, disease location, and surgical efficacy. However, there are significant data indicating no survival benefit for reoperation. This comprehensive literature review considering the controversial question of whether to operate for progressive or recurrent GBM seeks to evaluate the current available evidence and report on its conclusions.

Keywords: Extent of resection; Glioblastoma multiforme; Recurrence; Reoperation; Resection; Survival.

Publication types

Review

MeSH terms

Brain Neoplasms / mortality
Brain Neoplasms / surgery*
Glioblastoma / mortality
Glioblastoma / surgery*
Humans
Neoplasm Recurrence, Local / mortality
Neoplasm Recurrence, Local / surgery*
Prognosis
Quality of Life
Reoperation*