Neonatal Vitamin D Levels in Relation to Risk of Overweight at 7 Years in the Danish D-Tect Case-Cohort Study

Obes Facts. 2017;10(3):273-283. doi: 10.1159/000471881. Epub 2017 Jun 10.

Abstract

Background: Vitamin D level in pregnancy may be associated with risk of overweight in the offspring later in life.

Methods: In a case-cohort study based on Danish biobanks and registers we examined the association between 25-hydroxy-vitamin D (25(OH)D) level at birth and overweight at 7 years. Cases of overweight (n = 871) were randomly selected among 7-year-old children from the Copenhagen School Health Records Register (CSHRR) with a BMI above the 90th percentile. The cohort (n = 1,311) was a random sample selected among all Danish children born during the same period. Neonatal 25(OH)D was measured in dried blood spots.

Results: 25(OH)D3 exhibited the expected seasonal variation. Median level of 25(OH)D3 was 20.6 (11.9-33.3) nmol/l in the overweight group and 23.4 (13.5-34.3) nmol/l in the cohort. We found no association between neonatal 25(OH)D3 level and risk of overweight at age 7 years, neither in the crude model (OR (CI) 1.00 (0.99; 1.00)) nor in a model adjusted for maternal ethnicity, educational level, civil status, parity, season and year of birth, and offspring ponderal index (OR (CI) 1.00 (0.99; 1.01)).

Conclusion: Risk of overweight at 7 years of age was not associated with vitamin D level at birth.

Keywords: BMI; Case-cohort study; Childhood overweight; Dried blood spots; Epidemiology; Vitamin D, pregnancy.

MeSH terms

  • Body Mass Index
  • Calcifediol / blood
  • Child
  • Cohort Studies
  • Denmark / epidemiology
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Overweight / blood*
  • Overweight / epidemiology*
  • Pregnancy
  • Risk Factors
  • Seasons
  • Vitamin D / analogs & derivatives
  • Vitamin D / blood*
  • Vitamin D Deficiency

Substances

  • Vitamin D
  • 25-hydroxyvitamin D
  • Calcifediol