A new epipolythiodioxopiperazine with antibacterial and cytotoxic activities from the endophytic fungus Chaetomium sp. M336

Nat Prod Res. 2018 Mar;32(6):689-694. doi: 10.1080/14786419.2017.1338285. Epub 2017 Jun 12.

Abstract

A new compound 6-formamide-chetomin (1) together with chetomin (2) was isolated from solid fermentation products of the endophytic fungus Chaetomium sp. M336, which were elucidated by extensive spectroscopic analyses, including 1D and 2D NMR, and HR-ESI-MS experiments. The bioassay result showed that compound 1 had strong antibacterial activity against Escherichia coli, Staphylococcus aureus, Salmonella typhimurium ATCC 6539 and Enterococcus faecalis with minimum inhibitory concentration (MIC) value of 0.78 μg/mL; meanwhile it exhibited strong cytotoxicity with IC50 values of 21.6-27.1 nM against cell lines HeLa, SGC-7901 and A549.

Keywords: 6-Formamide-chetomin; Chaetomium sp. M336; antibacterial activities; chemical constituents; cytotoxicity; structure identification.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Chaetomium / chemistry*
  • Disulfides / chemistry
  • Disulfides / pharmacology
  • Endophytes / chemistry
  • Enterococcus faecalis / drug effects
  • Escherichia coli / drug effects
  • Formamides / chemistry
  • Formamides / pharmacology*
  • HeLa Cells
  • Humans
  • Indole Alkaloids / chemistry
  • Indole Alkaloids / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Salmonella typhimurium / drug effects
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Disulfides
  • Formamides
  • Indole Alkaloids
  • chetomin