Experimental pyelonephritis in the monkey. VII. Ascending pyelonephritis in the absence of vesicoureteral reflux

J Urol. 1985 Jun;133(6):1068-75. doi: 10.1016/s0022-5347(17)49382-7.


Six adult male nonrefluxing monkeys were experimentally infected by inoculation of P-fimbriated E. coli into the bladder. Eight control monkeys were inoculated with a non-P-fimbriated E. coli strain. Inoculation with the P-fimbriated E. coli resulted in marked leukocytosis, prolonged bacteriuria and loss of renal function with a 66 per cent incidence of pyelonephritis. Death secondary to bilateral pyelonephritis was seen in 2 monkeys inoculated with P-fimbriated E. coli. Pyelonephritis was not seen in any of the monkeys inoculated with non-P-fimbriated E. coli. The study shows that ascending pyelonephritis can occur in monkeys in the absence of vesicoureteral reflux.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chlorocebus aethiops
  • Escherichia coli / pathogenicity
  • Escherichia coli / ultrastructure
  • Escherichia coli Infections / physiopathology
  • Fimbriae, Bacterial / physiology
  • Kidney / pathology
  • Male
  • Pyelonephritis / etiology
  • Pyelonephritis / microbiology
  • Pyelonephritis / pathology
  • Pyelonephritis / physiopathology*
  • Urinary Bladder / microbiology
  • Vesico-Ureteral Reflux / complications
  • Vesico-Ureteral Reflux / physiopathology*