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Case Reports
. 2017 Jul;16(4):525-527.
doi: 10.1016/j.jcf.2017.05.008. Epub 2017 Jun 8.

Worsening Anxiety and Depression After Initiation of Lumacaftor/Ivacaftor Combination Therapy in Adolescent Females With Cystic Fibrosis

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Case Reports

Worsening Anxiety and Depression After Initiation of Lumacaftor/Ivacaftor Combination Therapy in Adolescent Females With Cystic Fibrosis

Cameron J McKinzie et al. J Cyst Fibros. .
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Abstract

In both phase III studies of LUM/IVA, as well as an extension study, worsening of mental health was not reported as a common side effect. Here we describe five cases in adolescent female patients that suggest a worsening of anxiety or depression associated with its use. In these five patients, two experienced suicidal ideation and three made suicide attempts that resulted in psychiatric hospitalizations.

Keywords: CFTR modulator; Cystic fibrosis.

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