Defective jejunal brush-border Na+/H+ exchange: a cause of congenital secretory diarrhoea

Lancet. 1985 May 11;1(8437):1066-9. doi: 10.1016/s0140-6736(85)92369-4.


In a child with congenital secretory diarrhoea, jejunal perfusion studies showed net water and electrolyte secretion and suggested a defect in sodium/proton exchange. A technique was developed for investigation of such exchange in brush-border membrane vesicles from jejunal biopsy specimens. Vesicles from control specimens displayed proton-gradient-dependent sodium uptake, whereas those from the patient did not. These findings, as well as pointing to a cause of congenital secretory diarrhoea, confirm the existence and importance of jejunal sodium/proton exchange in man.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Membrane / metabolism
  • Child
  • Child, Preschool
  • Diarrhea / congenital
  • Diarrhea / metabolism*
  • Female
  • Humans
  • Hydrogen / metabolism*
  • Infant
  • Infant, Newborn
  • Jejunum / metabolism*
  • Sodium / metabolism*


  • Hydrogen
  • Sodium