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Review
. 2017 May 26;8:80.
doi: 10.3389/fpsyt.2017.00080. eCollection 2017.

The Safety of Ingested Caffeine: A Comprehensive Review

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Free PMC article
Review

The Safety of Ingested Caffeine: A Comprehensive Review

Jennifer L Temple et al. Front Psychiatry. .
Free PMC article

Abstract

Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of caffeine include coffee, tea, and chocolate. Synthetic caffeine is also added to products to promote arousal, alertness, energy, and elevated mood. Over the past decade, the introduction of new caffeine-containing food products, as well as changes in consumption patterns of the more traditional sources of caffeine, has increased scrutiny by health authorities and regulatory bodies about the overall consumption of caffeine and its potential cumulative effects on behavior and physiology. Of particular concern is the rate of caffeine intake among populations potentially vulnerable to the negative effects of caffeine consumption: pregnant and lactating women, children and adolescents, young adults, and people with underlying heart or other health conditions, such as mental illness. Here, we review the research into the safety and safe doses of ingested caffeine in healthy and in vulnerable populations. We report that, for healthy adults, caffeine consumption is relatively safe, but that for some vulnerable populations, caffeine consumption could be harmful, including impairments in cardiovascular function, sleep, and substance use. We also identified several gaps in the literature on which we based recommendations for the future of caffeine research.

Keywords: adolescence; caffeine; children; energy drinks; pregnancy.

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References

    1. Nehlig A. Are we dependent upon coffee and caffeine? A review on human and animal data. Neurosci Biobehav Rev (1999) 23:563–76.10.1016/S0149-7634(98)00050-5 - DOI - PubMed
    1. Friedman M. Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas. Mol Nutr Food Res (2007) 51:116–34.10.1002/mnfr.200600173 - DOI - PMC - PubMed
    1. Dews PB. Caffeine. Annu Rev Nutr (1982) 2:323–41.10.1146/annurev.nu.02.070182.001543 - DOI - PubMed
    1. Lieberman HR, Wurtman RJ, Emde GG, Coviella IL. The effects of caffeine and aspirin on mood and performance. J Clin Psychopharmacol (1987) 7:315–20.10.1097/00004714-198710000-00004 - DOI - PubMed
    1. Frary CD, Johnson RK, Wang MQ. Food sources and intakes of caffeine in the diets of persons in the United States. J Am Diet Assoc (2005) 105:110–3.10.1016/j.jada.2004.10.027 - DOI - PubMed
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