LncRNA-mediated regulation of cell signaling in cancer

Oncogene. 2017 Oct 12;36(41):5661-5667. doi: 10.1038/onc.2017.184. Epub 2017 Jun 12.


To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered through functional genomics studies. Importantly, lncRNAs have been shown, in many cases, to function as master regulators for gene expression and thus, they can play a critical role in various biological functions and disease processes including cancer. Although the lncRNA-mediated gene expression involves various mechanisms, such as regulation of transcription, translation, protein modification, and the formation of RNA-protein or protein-protein complexes, in this review, we discuss the latest developments primarily in important cell signaling pathways regulated by lncRNAs in cancer.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasms / genetics*
  • RNA, Long Noncoding / genetics*
  • Signal Transduction / genetics*


  • RNA, Long Noncoding