CHOmine: an integrated data warehouse for CHO systems biology and modeling

Database (Oxford). 2017 Jan 1;2017:bax034. doi: 10.1093/database/bax034.

Abstract

The last decade has seen a surge in published genome-scale information for Chinese hamster ovary (CHO) cells, which are the main production vehicles for therapeutic proteins. While a single access point is available at www.CHOgenome.org, the primary data is distributed over several databases at different institutions. Currently research is frequently hampered by a plethora of gene names and IDs that vary between published draft genomes and databases making systems biology analyses cumbersome and elaborate. Here we present CHOmine, an integrative data warehouse connecting data from various databases and links to other ones. Furthermore, we introduce CHOmodel, a web based resource that provides access to recently published CHO cell line specific metabolic reconstructions. Both resources allow to query CHO relevant data, find interconnections between different types of data and thus provides a simple, standardized entry point to the world of CHO systems biology.

Database url: http://www.chogenome.org.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CHO Cells
  • Cricetinae
  • Cricetulus / genetics*
  • Data Warehousing
  • Databases, Genetic*
  • Genome*
  • Information Dissemination*
  • Models, Biological*
  • Systems Biology*