Which origin for polycystic ovaries syndrome: Genetic, environmental or both?

Ann Endocrinol (Paris). 2017 Jul;78(3):176-185. doi: 10.1016/j.ando.2017.04.024. Epub 2017 Jun 9.

Abstract

Polycystic ovaries syndrome (PCOS), the most common female endocrine disorder, affects 7-10% of women of childbearing age. It includes ovarian hyperandrogenism, impaired follicular maturation, anovulation and subfertility. Insulin resistance, although present in most cases, is not necessary for diagnosis. It increases hyperandrogenism and long-term metabolic, cardiovascular and oncological risks. The origin of hyperandrogenism and hyperinsulinemia has a genetic component, as demonstrated by familial aggregation studies and recent identification of associated genomic variants, conferring a particular susceptibility to the syndrome. However, experimental and epidemiological evidences also support a developmental origin via a deleterious foetal environment, concerning the endocrine status (foetal hyperandrogenism), the nutritional level (intrauterine growth retardation), or the toxicological exposure (endocrine disruptors). Epigenetic changes recently reported in the literature as associated with PCOS, enhance this hypothesis of foetal reprogramming of the future adult ovarian function by environmental factors. Better characterisation of these genetic, epigenetic, or environmental factors, could lead to earlier prevention and more efficient treatments.

Keywords: Environmental endocrine disruptors; Epigenetics; Foetal programming; Genomic variant; Hyperandrogenism; Hyperandrogénie ovarienne; Insulin resistance; Insulino-résistance; Maturation folliculaire; Perturbateurs endocriniens environnementaux; Polycystic ovaries syndrome; Programmation fœtale; SOPK; Variant génétique; Épigénétique.

Publication types

  • Review

MeSH terms

  • Adult
  • Environment
  • Environmental Illness* / etiology
  • Epigenesis, Genetic / physiology
  • Female
  • Gene-Environment Interaction*
  • Genetic Predisposition to Disease*
  • Humans
  • Polycystic Ovary Syndrome / etiology*
  • Polycystic Ovary Syndrome / genetics
  • Risk Factors