[Common therapeutic approaches of sarcopenia in the elderly and uremic myopathy]

Nephrol Ther. 2017 Dec;13(7):511-517. doi: 10.1016/j.nephro.2016.12.004. Epub 2017 Jun 9.
[Article in French]


The gradual loss of weight and function of muscle in patients with chronic kidney disease as in the elderly impacts the quality of life. Early management should help slow the functional limitation. Physical activity is the first therapy to propose that ensures stability of muscle mass and improved function. Resistance training programs have proven effective but are not yet widely available in nephrology units. The nutritional management should not be forgotten because there is a resistance to anabolism and protein intake should be involved in physical activity program. Associated treatments should not be neglected: vitamin D, anti-inflammatory, androgens. Some are still under evaluation. Therapeutic option, tomorrow, could be anti-myostatin antibodies and glitazones.

Keywords: Aging; Chronic kidney disease; Maladie rénale chronique; Muscle; Sarcopenia; Traitement; Treatment; Âge.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging
  • Diet Therapy / methods*
  • Exercise / physiology
  • Exercise Therapy / methods*
  • Humans
  • Muscular Diseases / etiology
  • Muscular Diseases / therapy*
  • Renal Insufficiency, Chronic / complications*
  • Renal Insufficiency, Chronic / therapy
  • Sarcopenia / etiology
  • Sarcopenia / therapy*
  • Uremia / complications