Effect of dietary fatty acid and micronutrient intake/energy ratio on serum diamine oxidase activity in healthy women

Nutrition. Jul-Aug 2017;39-40:67-70. doi: 10.1016/j.nut.2017.03.004. Epub 2017 Mar 28.


Objective: Serum diamine oxidase (DAO) activity varies to a greater extent in women than in men. DAO activity during the luteal phase was higher than that during the follicular phase in healthy women. Recent reports have indicated that duodenal lipid infusion increased DAO activity in the intestinal lymph in rats. The aim of this study was to elucidate the effect of dietary nutrient intake on serum DAO activity in healthy women.

Methods: Thirty-four healthy Japanese women were recruited. Food surveys were performed using dietary records for 3 d during both the follicular and luteal phases. Nutrient intake was calculated and expressed as the energy intake ratio. The correlation between DAO activity and nutrient intake was analyzed.

Results: Serum DAO activity in both phases was positively correlated with intake of long-chain fatty acids, saturated fatty acids, and monounsaturated fatty acids (P < 0.05). Intake of phosphorus, calcium, zinc, magnesium, iron, and vitamin B12 during the luteal phase was positively correlated with serum DAO activity (P < 0.05).

Conclusion: In healthy women, serum DAO activity was influenced by dietary fatty acid and micronutrient intake.

Keywords: Dietary fatty acids; Dietary micronutrients; Long-chain fatty acids; Menstrual cycle; Serum diamine oxidase activity.

MeSH terms

  • Adult
  • Amine Oxidase (Copper-Containing) / blood*
  • Dietary Fats / blood
  • Dietary Fats / pharmacology*
  • Energy Intake*
  • Fatty Acids / blood
  • Fatty Acids / pharmacology*
  • Female
  • Humans
  • Micronutrients / blood
  • Micronutrients / pharmacology*
  • Nutritional Status*
  • Young Adult


  • Dietary Fats
  • Fatty Acids
  • Micronutrients
  • Amine Oxidase (Copper-Containing)