Vitamin D endocrinology of bone mineralization

Marjolein van Driel; Johannes P T M van Leeuwen

doi:10.1016/j.mce.2017.06.008

Vitamin D endocrinology of bone mineralization

Mol Cell Endocrinol. 2017 Sep 15:453:46-51. doi: 10.1016/j.mce.2017.06.008. Epub 2017 Jun 9.

Authors

Marjolein van Driel¹, Johannes P T M van Leeuwen²

Affiliations

¹ Department of Internal Medicine, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands. Electronic address: m.vandriel@erasmusmc.nl.
² Department of Research and Education, Erasmus MC, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands. Electronic address: j.vanleeuwen@erasmusmc.nl.

PMID: 28606868
DOI: 10.1016/j.mce.2017.06.008

Abstract

Bone is a dynamic tissue that is strongly influenced by endocrine factors to restore the balance between bone resorption and bone formation. Bone formation involves the mineralization of the extracellular matrix formed by osteoblasts. In this process the role of vitamin D (1α,25(OH)₂D₃) is both direct and indirect. The direct effects are enabled via the Vitamin D Receptor (VDR); the outcome is dependent on the presence of other factors as well as origin of the osteoblasts, treatment procedures and species differences. Vitamin D stimulates mineralization of human osteoblasts but is often found inhibitory for mineralization of murine osteoblasts. In this review we will overview the current knowledge of the role of the vitamin D endocrine system in controlling the mineralization process in bone.

Keywords: Mineralization; Osteoblasts; VDR; Vitamin D.

Publication types

Review

MeSH terms

Animals
Bone and Bones / metabolism*
Calcification, Physiologic / physiology*
Cell Differentiation
Endocrine System / metabolism*
Gene Expression Regulation
Humans
Mice
Osteoblasts / metabolism
Osteogenesis
Receptors, Calcitriol / metabolism*
Species Specificity
Vitamin D / metabolism*

Substances

Receptors, Calcitriol
Vitamin D