Clinical Usefulness of Somatostatin Receptor Scintigraphy in Japanese Patients with Gastroenteropancreatic Neuroendocrine Tumors

Digestion. 2017;96(1):13-20. doi: 10.1159/000470838. Epub 2017 Jun 14.

Abstract

Background/aims: Somatostatin receptor (SSTR) scintigraphy (SRS) is the standard imaging modality for evaluation of gastroenteropancreatic neuroendocrine tumor (GEP-NET) in Western countries. However, this modality was not approved in Japan until recently. The purpose of this study was to evaluate the clinical efficacy of SRS for detecting GEP-NET in Japanese patients.

Methods: Japanese patients with advanced GEP-NET were enrolled and evaluated by the SRS and CT. We also compared SRS and immunohistochemical expression of SSTR type 2a (SSTR2a).

Results: We enrolled 16 patients and the primary sites were the pancreas in 9, the stomach in 1, the small intestine in 2, the colon in 3, and unknown in 1. SRS showed positive findings in 3 (100%) of grade 1 (G1) and in 12 (92.3%) of grade 2 (G2) lesions. In the liver, SRS and CT detected lesions in 13 and 14 cases, respectively. The concordance rate of SSTR2a expression with SRS findings was 93.8% in the whole body and 92.9% in the liver.

Conclusions: SRS could detect almost all of G1 and G2. SRS could be useful to detect lesions, with a high concordance rate with CT and pathological findings. We confirmed that SRS is a useful and reliable modality for Japanese patients.

Keywords: 111In-pentetreotide; Gastroenteropancreatic neuroendocrine tumor; Immunohistochemistry; Neuroendocrine tumor; SRS (111In-octreotide somatostatin receptor scintigraphy); Somatostatin receptor scintigraphy.

Publication types

  • Evaluation Study

MeSH terms

  • Adult
  • Aged
  • Female
  • Humans
  • Immunohistochemistry
  • Intestinal Neoplasms / diagnostic imaging*
  • Intestinal Neoplasms / pathology*
  • Japan
  • Liver / diagnostic imaging
  • Liver / pathology
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Neuroendocrine Tumors / diagnostic imaging*
  • Neuroendocrine Tumors / pathology*
  • Pancreatic Neoplasms / diagnostic imaging*
  • Pancreatic Neoplasms / pathology*
  • Pentetic Acid / administration & dosage
  • Pentetic Acid / analogs & derivatives
  • Radionuclide Imaging / methods*
  • Receptors, Somatostatin / metabolism*
  • Somatostatin / metabolism
  • Stomach Neoplasms / diagnostic imaging*
  • Stomach Neoplasms / pathology*
  • Tomography, X-Ray Computed

Substances

  • (111)indium-DTPA-D-phe octreoide
  • Receptors, Somatostatin
  • SSTR2 protein, human
  • Somatostatin
  • Pentetic Acid

Supplementary concepts

  • Gastro-enteropancreatic neuroendocrine tumor