Involvement of platelet activating factor in physiological stress in the lizard, Anolis carolinensis

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1985;81(1):81-6. doi: 10.1016/0742-8413(85)90095-7.


Platelet activating factor (PAF) and 1-O-alkyl-linked choline-containing phosphoglycerides have been identified in the blood of the lizard, Anolis carolinensis. The level of PAF in the blood of chronically stressed lizards is 250% higher than in that of controls; the blood contains sufficient 1-O-alkyl-linked choline-containing phosphoglycerides to support the synthesis of PAF. Incorporation of PAF is higher in the liver than in the blood; control animals incorporate more PAF than chronically stressed animals. "Lyso"-PAF is the major metabolite in the blood; whereas, in the liver both "lyso"-PAF and "acyl"-PAF are predominant products. 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine:acetylhydrolase activity in the chronically stressed or corticosterone-implanted lizards is increased 2- to 3-fold over the control. Involvement of PAF in the physiological response to psychological stress is indicated.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Carboxylic Ester Hydrolases / blood
  • Kinetics
  • Liver / metabolism
  • Lizards / physiology*
  • Male
  • Platelet Activating Factor / isolation & purification
  • Platelet Activating Factor / pharmacology
  • Platelet Activating Factor / physiology*
  • Platelet Aggregation / drug effects
  • Rabbits
  • Stress, Physiological / physiopathology*


  • Platelet Activating Factor
  • 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine-acetylhydrolase
  • Carboxylic Ester Hydrolases