Protein Interaction and Na/K-ATPase-Mediated Signal Transduction

Molecules. 2017 Jun 14;22(6):990. doi: 10.3390/molecules22060990.


The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In addition to pumping ions across cell membrane, it is engaged in assembly of multiple protein complexes in the plasma membrane. This assembly allows NKA to perform many non-pumping functions including signal transduction that are important for animal physiology and disease progression. This article will focus on the role of protein interaction in NKA-mediated signal transduction, and its potential utility as target for developing new therapeutics.

Keywords: Na/K-ATPase; Src; cardiotonic steroids; drug target; signal transduction.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Membrane / chemistry
  • Cell Membrane / genetics*
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / genetics*
  • Protein Interaction Maps / genetics*
  • Signal Transduction / genetics
  • Sodium-Potassium-Exchanging ATPase / chemistry
  • Sodium-Potassium-Exchanging ATPase / genetics*


  • Multiprotein Complexes
  • Sodium-Potassium-Exchanging ATPase