Effects of nonsteroidal anti-inflammatory drugs on prostaglandins and renal function

Am J Med. 1985 Jun;78(6 Pt 1):992-1000. doi: 10.1016/0002-9343(85)90223-2.

Abstract

In the past 15 years, there has been an explosion in the number of nonsteroidal anti-inflammatory drugs on the market. Along with this explosion have come increasing reports of the physiologic and pathologic changes seen in the kidneys. This report reviews the effects of prostaglandins on the kidney and the physiologic changes that result when prostaglandin synthesis is blocked. The world literature on renal complications of nonsteroidal anti-inflammatory drugs is reviewed and 274 cases of acute renal disease associated with their use are reported. The following cases are described: nephrotic syndrome (34); acute interstitial nephritis (51); acute tubular necrosis (29); papillary necrosis (53); poor perfusion with renal failure (40); acute glomerulitis or vasculitis (13); and unspecified renal failure (102). Fenoprofen appeared to be more nephrotoxic than other nonsteroidal anti-inflammatory drugs and resulted in multiple renal lesions in the same patient.

Publication types

  • Review

MeSH terms

  • Anti-Inflammatory Agents / adverse effects
  • Anti-Inflammatory Agents / pharmacology*
  • Aspirin / adverse effects
  • Aspirin / pharmacology
  • Epoprostenol / biosynthesis
  • Epoprostenol / physiology
  • Fenoprofen / adverse effects
  • Fenoprofen / pharmacology
  • Glafenine / adverse effects
  • Glafenine / pharmacology
  • Glomerular Filtration Rate / drug effects
  • Glomerulonephritis / physiopathology
  • Humans
  • Indomethacin / adverse effects
  • Indomethacin / pharmacology
  • Kidney / blood supply
  • Kidney / physiology*
  • Kidney / physiopathology
  • Nephritis, Interstitial / etiology
  • Nephritis, Interstitial / physiopathology
  • Nephrotic Syndrome / etiology
  • Nephrotic Syndrome / physiopathology
  • Phenacetin / adverse effects
  • Phenacetin / pharmacology
  • Phenylbutazone / adverse effects
  • Phenylbutazone / pharmacology
  • Prostaglandins / biosynthesis*
  • Prostaglandins / physiology
  • Regional Blood Flow / drug effects
  • Renin-Angiotensin System / drug effects
  • T-Lymphocytes / physiology

Substances

  • Anti-Inflammatory Agents
  • Prostaglandins
  • Glafenine
  • Epoprostenol
  • Phenacetin
  • Phenylbutazone
  • Aspirin
  • Fenoprofen
  • Indomethacin