The Effects of Latanoprost With Benzalkonium Chloride Versus Travoprost With SofZia on the Ocular Surface

Eye Contact Lens. 2018 Nov;44 Suppl 2:S93-S98. doi: 10.1097/ICL.0000000000000405.


Purpose: To assess ocular surface changes in participants using latanoprost with benzalkonium chloride (Xalatan) and travoprost with SofZia (Travatan Z).

Methods: In this prospective, open-label, nonrandomized cohort study, participants were classified into two groups: group 1 (n=28) naive to glaucoma therapy, group 2 (n=27) on previous Xalatan monotherapy in both eyes. Both groups started (or continued) Xalatan in the right eye and Travatan Z in the left eye. Baseline, 1-, and 2-month measurements of tear breakup time (TBUT), corneal staining score, conjunctival staining score, conjunctival hyperemia score, tear production, and intraocular pressure were obtained. The Ocular Surface Disease Index questionnaire measured participants' comfort and dryness symptoms. Medication preference was recorded.

Results: Data were collected from 55 participants. Tear breakup time at baseline and 1-month follow-up in group 1 was significantly longer than that of group 2 (P=0.005). At 2 months, there was no significant difference in TBUT between the two groups (P=0.779). Tear production in group 1 at all three time points was significantly higher than group 2 (P<0.05). Conjunctival staining score at 2 months in group 1 was significantly higher than group 2 (P=0.031). There was no significant difference in other parameters between the groups at any other time point. No significant difference in any parameter was found between Xalatan and Travatan Z (intragroup comparison).

Conclusions: Significant differences in ocular surface characteristics were detected between groups, but no significant difference was detected between participants treated with Xalatan and Travatan Z.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Antihypertensive Agents / adverse effects
  • Antihypertensive Agents / pharmacology
  • Antihypertensive Agents / therapeutic use*
  • Benzalkonium Compounds / adverse effects
  • Benzalkonium Compounds / pharmacology
  • Benzalkonium Compounds / therapeutic use*
  • Conjunctiva / drug effects*
  • Conjunctiva / pathology
  • Cornea / drug effects*
  • Cornea / pathology
  • Female
  • Glaucoma / drug therapy*
  • Glaucoma / pathology
  • Humans
  • Intraocular Pressure
  • Latanoprost / adverse effects
  • Latanoprost / pharmacology
  • Latanoprost / therapeutic use*
  • Male
  • Middle Aged
  • Preservatives, Pharmaceutical / adverse effects
  • Preservatives, Pharmaceutical / pharmacology
  • Preservatives, Pharmaceutical / therapeutic use*
  • Prospective Studies
  • Tears / metabolism
  • Travoprost / adverse effects
  • Travoprost / pharmacology
  • Travoprost / therapeutic use*


  • Antihypertensive Agents
  • Benzalkonium Compounds
  • Preservatives, Pharmaceutical
  • Latanoprost
  • Travoprost