Abstract
We have disclosed our effort to develop caffeic acid derivatives as potent and non-toxic inhibitors of α-MSH-stimulated melanogenesis to treat pigmentation disorders and skin medication including a cosmetic skin-whitening agent. The SAR studies revealed that cyclohexyl ester and secondary amide derivatives of caffeic acid showed significant inhibitory activities.
Keywords:
Caffeamide; Caffeic acid; Melanogenesis; Skin whitening; α-MSH.
Copyright © 2017 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Caffeic Acids / chemical synthesis
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Caffeic Acids / chemistry
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Caffeic Acids / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Dose-Response Relationship, Drug
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Mice
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Molecular Structure
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Skin Lightening Preparations / chemical synthesis
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Skin Lightening Preparations / chemistry
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Skin Lightening Preparations / pharmacology*
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Skin Pigmentation / drug effects*
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Structure-Activity Relationship
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alpha-MSH / antagonists & inhibitors*
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alpha-MSH / metabolism
Substances
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Caffeic Acids
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Skin Lightening Preparations
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alpha-MSH
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caffeic acid