Comparative Studies of Reaction of Cobalamin (II) and Cobinamide (II) With Sulfur Dioxide

J Biol Inorg Chem. 2017 Aug;22(6):969-975. doi: 10.1007/s00775-017-1474-z. Epub 2017 Jun 15.

Abstract

The kinetics of reactions of cobalamin (II) and cobinamide (II) with sulfur dioxide was studied by UV-visible (UV-vis) spectroscopy. Reaction results in oxidation of Co(II) center and involves two aquated SO2 moieties. The final product is suggested to be complex Co(III)-S2O 4•- . The absence of corrin ring modifications during the reactions was proved.

Keywords: Cobalamin; Cobinamide; Kinetics; Redox reactions; Sulfur dioxide.

Publication types

  • Comparative Study

MeSH terms

  • Cobamides / chemistry*
  • Kinetics
  • Sulfur Dioxide / chemistry*
  • Vitamin B 12 / chemistry*

Substances

  • Cobamides
  • Sulfur Dioxide
  • cobinamide
  • Vitamin B 12