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. 2018 Jan;43(2):445-453.
doi: 10.1038/npp.2017.125. Epub 2017 Jun 16.

Telomere Length and Bipolar Disorder

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Free PMC article

Telomere Length and Bipolar Disorder

Timothy R Powell et al. Neuropsychopharmacology. .
Free PMC article

Erratum in

  • Telomere Length and Bipolar Disorder.
    Powell TR, Dima D, Frangou S, Breen G. Powell TR, et al. Neuropsychopharmacology. 2018 Jan;43(2):454. doi: 10.1038/npp.2017.239. Neuropsychopharmacology. 2018. PMID: 29230034 Free PMC article.

Abstract

Variation in telomere length is heritable and is currently considered a promising biomarker of susceptibility for neuropsychiatric disorders, particularly because of its association with memory function and hippocampal morphology. Here, we investigate telomere length in connection to familial risk and disease expression in bipolar disorder (BD). We used quantitative PCRs and a telomere-sequence to single-copy-gene-sequence ratio method to determine telomere length in genomic DNA extracted from buccal smears from 63 patients with BD, 74 first-degree relatives (49 relatives had no lifetime psychopathology and 25 had a non-BD mood disorder), and 80 unrelated healthy individuals. Participants also underwent magnetic resonance imaging to determine hippocampal volumes and cognitive assessment to evaluate episodic memory using the verbal paired associates test. Telomere length was shorter in psychiatrically well relatives (p=0.007) compared with unrelated healthy participants. Telomere length was also shorter in relatives (regardless of psychiatric status; p<0.01) and patients with BD not on lithium (p=0.02) compared with lithium-treated patients with BD. In the entire sample, telomere length was positively associated with left and right hippocampal volume and with delayed recall. This study provides evidence that shortened telomere length is associated with familial risk for BD. Lithium may have neuroprotective properties that require further investigation using prospective designs.

Figures

Figure 1
Figure 1
Scatterplot showing the distribution of adjusted telomere length in the study sample. Compared with unrelated healthy individuals, age- and sex-adjusted telomere length was shorter in psychiatrically well relatives and in relatives with psychiatric diagnoses relative to controls (p=0.07; not shown in figure). Lithium-treated patients with BD had longer telomere length compared with relatives, regardless of psychiatric status, and patients with BD not on lithium.
Figure 2
Figure 2
Scatterplot of the association between telomere length, hippocampal volume, and delayed memory in the study sample. In the entire sample, telomere length was positively associated with left (a) and (b) right hippocampal volume and with (c) delayed recall in the verbal paired associates test.

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