ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity

Mol Cell. 2017 Jun 15;66(6):731-733. doi: 10.1016/j.molcel.2017.05.037.


A new mechanism linking ER dysfunction to metabolic inflammation is discovered in a recent study by Shan et al. (2017), which demonstrated ER stress-induced rewiring of adipose tissue macrophage polarization by IRE1α activation, leading to impaired systemic glucose homeostasis.

MeSH terms

  • Adipose Tissue
  • Homeostasis
  • Humans
  • Inflammation
  • Macrophages*
  • Obesity*