Detection of yellow fever virus genomes from four imported cases in China

Int J Infect Dis. 2017 Jul;60:93-95. doi: 10.1016/j.ijid.2017.05.001. Epub 2017 Jun 13.

Abstract

Yellow fever virus (YFV), as the first proven human-pathogenic virus, is still a major public health problem with a dramatic upsurge in recent years. This is a report on four imported cases of yellow fever virus into China identified by whole genome sequencing. Phylogenetic analysis was performed and the results showed that these four viruses were highly homologous with Angola 71 strains (AY968064). In addition, effective mutations of amino acids were not observed in the E protein domain of four viruses, thus confirming the effectiveness of the YFV-17D vaccine (X03700). Although there is low risk of local transmission in most part of China, the increasing public health risk of YF caused by international exchange should not be ignored.

Keywords: Phylogenetic analysis; Urine sample; Vaccine effectiveness; Whole genome sequencing; Yellow fever virus.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Angola
  • China
  • Genome, Viral*
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Phylogeny
  • RNA, Viral / blood
  • RNA, Viral / isolation & purification
  • RNA, Viral / urine
  • Travel
  • Viral Proteins / chemistry
  • Viral Proteins / genetics
  • Whole Genome Sequencing
  • Yellow Fever / blood
  • Yellow Fever / urine
  • Yellow Fever / virology*
  • Yellow Fever Vaccine / genetics
  • Yellow Fever Vaccine / immunology
  • Yellow fever virus / classification
  • Yellow fever virus / genetics*
  • Yellow fever virus / immunology

Substances

  • RNA, Viral
  • Viral Proteins
  • Yellow Fever Vaccine