Salvage of the Foot for Recurrent Malignant Peripheral Nerve Sheath Tumor

J Foot Ankle Surg. 2017 Nov-Dec;56(6):1263-1268. doi: 10.1053/j.jfas.2017.04.029. Epub 2017 Jun 13.


Malignant peripheral nerve sheath tumors are rare soft tissue tumors accounting for 3% to 10% of all soft tissue tumors. They are strongly related to neurofibromatosis type 1, an autosomal dominant disease, and are characterized by aggressive biologic behavior, high local recurrence rates, and frequent metastases. Although the major nerves of the lower extremities are a common location of these tumors, scarce cases have been reported of malignant peripheral nerve sheath tumors involving the interdigital nerves of the foot. We report the case of a patient with non-neurofibromatosis type 1 and a recurrent malignant peripheral nerve sheath tumor of the first interdigital nerve of the foot treated successfully with limb salvage surgery with wide resection margins and reconstruction with an autogenous fibula graft.

Keywords: bone graft; foot; limb salvage; malignant peripheral nerve sheath tumor.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Autografts
  • Biopsy, Needle
  • Bone Transplantation / methods*
  • Female
  • Fibula / surgery
  • Follow-Up Studies
  • Foot / surgery
  • Humans
  • Immunohistochemistry
  • Limb Salvage / methods*
  • Nerve Sheath Neoplasms / pathology
  • Nerve Sheath Neoplasms / surgery
  • Neurofibromatosis 1 / pathology*
  • Neurofibromatosis 1 / surgery*
  • Peripheral Nervous System Neoplasms / pathology
  • Peripheral Nervous System Neoplasms / surgery*
  • Plastic Surgery Procedures / methods
  • Risk Assessment
  • Soft Tissue Neoplasms / pathology
  • Soft Tissue Neoplasms / surgery*
  • Treatment Outcome