Predictive value of cranial ultrasound in the newborn baby: a reappraisal

Lancet. 1985 Jul 20;2(8447):137-40. doi: 10.1016/s0140-6736(85)90237-5.


During a 36-month period 435 babies of 34 weeks' gestation or less were regularly scanned with ultrasound. A large periventricular/intraventricular haemorrhage developed in 40 babies, and extensive cystic leucomalacia developed in 10. The neurodevelopmental outcome and the frequency of handicap in these 2 groups were compared. 9 of the 18 survivors with a large haemorrhage were found to be completely normal and only 2 showed a major handicap. However, severe cerebral palsy with mental retardation developed in all the survivors with extensive cystic leucomalacia, and 4 of the 7 babies were also cortically blind. These findings suggest that the size of the haemorrhage is not a good predictor of outcome, but that severe cystic leucomalacia is associated with a very poor prognosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / pathology
  • Cerebral Hemorrhage / diagnosis*
  • Cerebral Hemorrhage / pathology
  • Cerebral Ventricles / pathology
  • Child Development
  • Follow-Up Studies
  • Humans
  • Infant, Newborn
  • Neurologic Examination
  • Prognosis
  • Ultrasonography*