Vascular ageing: Underlying mechanisms and clinical implications

Exp Gerontol. 2018 Aug;109:16-30. doi: 10.1016/j.exger.2017.06.007. Epub 2017 Jun 15.

Abstract

Epidemiological studies have shown that ageing is a major non-reversible risk factor for cardiovascular disease. Vascular ageing starts early in life and is characterized by a gradual change of vascular structure and function resulting in increased arterial stiffening. At the present review we discuss the role of the most important molecular pathways involved in vascular ageing, their association with arterial stiffening and possible novel therapeutic targets that may delay this otherwise irreversible degenerating process. Specifically, we discuss the role of oxidative stress, telomere shortening, and ubiquitin proteasome system in endothelial cell senescence and dysfunction in vascular inflammation and in arterial stiffening. Further, we summarize the most important molecular mechanisms regulating vascular ageing including sirtuin 1, telomerase, klotho, JunD, and amyloid beta 1-40 peptide.

Keywords: Amyloid beta; Arterial stiffness; JunD; Klotho; Sirtuin1; Telomere length; Vascular ageing.

Publication types

  • Review

MeSH terms

  • Aging / physiology*
  • Amyloid beta-Peptides / physiology
  • Animals
  • Blood Vessels / physiology*
  • Endothelial Cells / physiology
  • Humans
  • Lamin Type A / physiology
  • Oxidative Stress
  • Sirtuin 1 / physiology
  • Telomere
  • Vascular Stiffness

Substances

  • Amyloid beta-Peptides
  • Lamin Type A
  • prelamin A
  • Sirtuin 1