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. 2017 Aug;56:92-101.
doi: 10.1016/j.dnarep.2017.06.011. Epub 2017 Jun 9.

Histone Ubiquitination in the DNA Damage Response

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Histone Ubiquitination in the DNA Damage Response

Michael Uckelmann et al. DNA Repair (Amst). .
Free article


DNA double strand breaks need to be repaired in an organized fashion to preserve genomic integrity. In the organization of faithful repair, histone ubiquitination plays a crucial role. Recent findings suggest an integrated model for DNA repair regulation through site-specific histone ubiquitination and crosstalk to other posttranslational modifications. Here we discuss how site-specific histone ubiquitination is achieved on a molecular level and how different multi-protein complexes work together to integrate different histone ubiquitination states. We propose a model where site-specific H2A ubiquitination organizes the spatio-temporal recruitment of DNA repair factors which will ultimately contribute to DNA repair pathway choice between homologous recombination and non-homologous end joining.

Keywords: BRCA1/BARD1; BRE1; DNA damage response; Histone ubiquitination; PRC1; RNF168.

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