Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome

Clin Chim Acta. 2017 Aug:471:243-247. doi: 10.1016/j.cca.2017.06.013. Epub 2017 Jun 15.


Background: Polycystic ovary syndrome (PCOS) is commonly characterized by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Following the reported relationship between phoenixin-14 and gonadotropin production in rat hypothalamic-pituitary-gonadal axis, the present study was designed to investigate the circulating concentrations of phoenixin-14 and their associations with the concentrations of sex hormones including luteinizing hormone (LH), follicular stimulating hormone (FSH), estradiol (E2), progesterone (P4) and total testosterone (TT) in PCOS patients.

Methods: A total of 41 women with diagnosed PCOS using Rotterdam criteria and 37 healthy individuals were enrolled in the study.

Results: Serum phoenixin-14 concentration in PCOS patients (n=41) was 0.515±0.044ng/ml, significantly higher than that in healthy controls (0.289±0.046ng/ml, n=37). PCOS patients had higher serum LH, dehydroepiandrosterone and fasting blood glucose concentrations, and higher index of homeostasis model of assessment-IR than those in healthy women. Correlation analysis showed significantly positive correlations of phoenixin-14 with LH, FSH, TT, P4, BMI and nesfatin-1 concentrations, and significantly negative correlations with E2 and serum insulin (FSI) concentrations, respectively.

Conclusions: Compared to control women, PCOS patients had significantly increased serum phoenixin-14, LH and androgen concentrations. The positive correlations of phoenixin-14 concentrations with LH and TT concentrations suggest a possible role of phoenixin-14 in the development of PCOS.

Keywords: LH; Phoenixin; Polycystic ovary syndrome.

MeSH terms

  • Adult
  • Calcium-Binding Proteins / blood*
  • DNA-Binding Proteins / blood*
  • Female
  • Humans
  • Luteinizing Hormone / blood*
  • Nerve Tissue Proteins / blood*
  • Neuropeptides / blood*
  • Nucleobindins
  • Polycystic Ovary Syndrome / blood*
  • Young Adult


  • Calcium-Binding Proteins
  • DNA-Binding Proteins
  • NUCB2 protein, human
  • Nerve Tissue Proteins
  • Neuropeptides
  • Nucb1 protein, rat
  • Nucleobindins
  • Luteinizing Hormone