The nuclear pore complex core scaffold and permeability barrier: variations of a common theme

Curr Opin Cell Biol. 2017 Jun:46:110-118. doi: 10.1016/ Epub 2017 Jun 15.


The study of the nuclear pore complex (NPC) is a fascinating endeavor, as it not only implies uncovering the 'engineering marvel' of its architecture and function, but also provides a key window into a significant evolutionary event: the origin of the eukaryotic cell. The combined efforts of many groups in the field, with the help of novel methodologies and new model organisms, are facilitating a much deeper understanding of this complex assembly. Here we cover recent advances on the characterization of the structure of the NPC scaffold and of the biophysical mechanisms that define the permeability barrier. We identify common architectural and functional principles between those two NPC compartments, expanding the previous protocoatomer hypothesis to suggest possible evolutionary origins for the FG nucleoporins and the NPC permeability barrier.

Publication types

  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Cell Nucleus / metabolism
  • Eukaryotic Cells / cytology*
  • Eukaryotic Cells / metabolism
  • Evolution, Molecular
  • Nuclear Pore / chemistry
  • Nuclear Pore / metabolism
  • Nuclear Pore Complex Proteins / chemistry
  • Nuclear Pore Complex Proteins / metabolism*


  • Nuclear Pore Complex Proteins