Transpulmonary thermodilution: advantages and limits

Crit Care. 2017 Jun 19;21(1):147. doi: 10.1186/s13054-017-1739-5.


Background: For complex patients in the intensive care unit or in the operating room, many questions regarding their haemodynamic management cannot be answered with simple clinical examination. In particular, arterial pressure allows only a rough estimation of cardiac output. Transpulmonary thermodilution is a technique that provides a full haemodynamic assessment through cardiac output and other indices.

Main body: Through the analysis of the thermodilution curve recorded at the tip of an arterial catheter after the injection of a cold bolus in the venous circulation, transpulmonary thermodilution intermittently measures cardiac output. This measure allows the calibration of pulse contour analysis. This provides continuous and real time monitoring of cardiac output, which is not possible with the pulmonary artery catheter. Transpulmonary thermodilution provides several variables beyond cardiac output. It estimates the end-diastolic volume of the four cardiac cavities, which is a marker of cardiac preload. It provides an estimation of the systolic function of the combined ventricles. It is more direct than the pulmonary artery catheter, but does not allow the distinct estimation of right and left cardiac function. It is easier and faster to perform than echocardiography, but does not provide a full evaluation of the cardiac structure and function. Transpulmonary thermodilution has the unique advantage of being able to estimate at the bedside extravascular lung water, which quantifies the volume of pulmonary oedema, and pulmonary vascular permeability, which quantifies the degree of a pulmonary capillary leak. Both indices are helpful for guiding fluid strategy, especially in case of acute respiratory distress syndrome.

Conclusions: Transpulmonary thermodilution provides a full cardiovascular evaluation that allows one to answer many questions regarding haemodynamic management. It belongs to the category of "advanced" devices that are indicated for the most critically ill and/or complex patients.

Keywords: Cardiac output; Cardiac preload; Extravascular lung water; Fluid responsiveness; Haemodynamic monitoring.

Publication types

  • Review

MeSH terms

  • Cardiac Output / physiology
  • Catheterization, Swan-Ganz / methods
  • Catheterization, Swan-Ganz / standards
  • Critical Illness / therapy*
  • Hemodynamics / physiology
  • Humans
  • Intensive Care Units / organization & administration
  • Monitoring, Physiologic / methods*
  • Monitoring, Physiologic / standards
  • Pulse Wave Analysis / methods
  • Thermodilution / methods*
  • Thermodilution / standards*