Effect of Conjugated Linoleic Acid Intake on Endurance Exercise Performance and Anti-fatigue in Student Athletes

J Oleo Sci. 2017 Jul 1;66(7):723-733. doi: 10.5650/jos.ess17053. Epub 2017 Jun 13.


Conjugated linoleic acids (CLA) intake has been reported to reduce body fat mass or increase lean body mass and to improve exercise outcome by modulating testosterone in humans. These reports have studied mostly overweight subjects; few were athletes. Therefore, in this study, the effect of CLA intake on endurance performance and anti-fatigue in student athletes was investigated. A double-blind, crossover study was conducted with 10 male student athletes. Each subject was administered with either CLA (net 0.9 g/day) or a placebo for 14 days. They were subjected to an exercise tolerance test (steady loading) using a cycle ergometer on days 0 and 14. Peak VO2 was determined for each subject using a graded loading test. The steady loading test was performed with a pedaling exercise load of 50% peak VO2 for 40 min and then with a load of 70% peak VO2 until exhaustion. Blood sampling and measurement of critical flicker frequency (CFF) were performed before and after exercise. The rate of perceived exertion (RPE) was measured serially during exercise. In the results, amount of body weight variation significantly increased and amount of body fat percentage variation tended to decrease by CLA intake, it might have an effect by increase in muscle mass. In addition, amount of exercise time variation significantly increased, amount of variation of CFF before and after exercise tended to increase, that of RPE during exercise tended to decrease, and that of creatine phosphokinase before and after exercise tended to decrease in the CLA group. These results suggested that CLA intake for 14 days might have an effect on endurance performance and anti-fatigue in student athletes.

Keywords: anti-fatigue; conjugated linoleic acid; endurance performance; ergogenic.

MeSH terms

  • Adipose Tissue / metabolism
  • Adolescent
  • Adult
  • Athletes*
  • Body Weight
  • Creatine Kinase / blood
  • Cross-Over Studies
  • Double-Blind Method
  • Exercise / physiology*
  • Exercise Test
  • Exercise Tolerance / drug effects*
  • Fatigue / prevention & control*
  • Humans
  • Linoleic Acids, Conjugated / administration & dosage*
  • Linoleic Acids, Conjugated / pharmacology*
  • Male
  • Physical Endurance / drug effects*
  • Physical Exertion / drug effects
  • Testosterone / metabolism
  • Young Adult


  • Linoleic Acids, Conjugated
  • Testosterone
  • Creatine Kinase