Perspective of αvβ6-Integrin Imaging for Clinical Management of Pancreatic Carcinoma and Its Precursor Lesions

Mol Imaging. 2017 Jan 1:16:1536012117709384. doi: 10.1177/1536012117709384.

Abstract

ß6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αvß6-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel αvß6-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer.

Keywords: cancer detection imaging; cancer imaging; clinical translation of novel oncologic radiotracers; immunohistochemistry; integrin.

Publication types

  • Comment

MeSH terms

  • Antigens, Neoplasm / metabolism*
  • Carcinoma, Pancreatic Ductal / metabolism
  • Humans
  • Immunohistochemistry
  • Integrins / metabolism*
  • Pancreatic Neoplasms / diagnostic imaging*
  • Positron-Emission Tomography

Substances

  • Antigens, Neoplasm
  • Integrins
  • integrin alphavbeta6