Improvement of avoidance acquisition by the nootropic drug oxiracetam in mice

Arch Int Pharmacodyn Ther. 1985 May;275(1):86-92.


The nootropic drug, oxiracetam (25 or 50 mg/kg i.p.), was tested in two inbred strains of mice, subjected to shuttle-box avoidance training. The drug improved avoidance acquisition in good performers BALB/c mice more than in poor performers C57BL/6 mice. In both cases the avoidance facilitating action was evident only if training was preceded by a five-day pretreatment. The nootropic prototype, piracetam (100 mg/kg), facilitated avoidance acquisition in pretreated BALB/c, but not in C57BL/6 mice.

MeSH terms

  • Animals
  • Avoidance Learning / drug effects*
  • Central Nervous System Stimulants / pharmacology*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Piracetam / pharmacology
  • Pyrrolidines / pharmacology*
  • Species Specificity


  • Central Nervous System Stimulants
  • Pyrrolidines
  • oxiracetam
  • Piracetam