Association of vitamin D intake and serum levels with fertility: results from the Lifestyle and Fertility Study

Fertil Steril. 2017 Aug;108(2):302-311. doi: 10.1016/j.fertnstert.2017.05.037. Epub 2017 Jun 16.

Abstract

Objective: To evaluate the role of vitamin D intake and serum levels on conception of clinical pregnancy and live birth.

Design: Prospective cohort study.

Setting: Academic medical centers.

Patient(s): Healthy, nulliparous women, age 18-39 years, and their male partners.

Intervention(s): None.

Main outcome measure(s): Clinical pregnancy and live birth were compared between those who did or did not meet the vitamin D estimated average requirement (EAR) intake (10 μg/d) and with serum 25-hydroxyvitamin D (25(OH)D) considered at risk for inadequacy or deficiency (<50 nmol/L) or sufficient (≥50 nmol/L).

Result(s): Among 132 women, 37.1% did not meet the vitamin D EAR and 13.9% had serum levels at risk for inadequacy or deficiency. Clinical pregnancies were significantly higher among women who met the vitamin D EAR (67.5% vs. 49.0%) and with sufficient serum 25(OH)D (64.3% vs. 38.9%) compared with those who did not. Live births were higher among those who met the vitamin D EAR (59.0% vs. 40.0%). The adjusted odds ratio (AOR) of conceiving a clinical pregnancy was significantly higher among those who met the EAR (AOR = 2.26; 95% confidence interval [CI], 1.05-4.86) and had sufficient serum 25(OH)D (AOR = 3.37; 95% CI, 1.06-10.70). The associations were not significant after controlling for selected nutrients and dietary quality.

Conclusion(s): Women with vitamin D intake below EAR and serum 25(OH)D levels at risk for inadequacy or deficiency may be less likely to conceive and might benefit from increased vitamin D intake to achieve adequacy.

Clinical trial registration number: NCT00642590.

Keywords: Vitamin D; fertility; pregnancy; serum 25(OH)D.

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Age Distribution
  • Dietary Supplements / statistics & numerical data
  • Female
  • Humans
  • Live Birth / epidemiology*
  • Pregnancy / blood
  • Pregnancy / statistics & numerical data
  • Pregnancy Complications / blood
  • Pregnancy Complications / diet therapy*
  • Pregnancy Complications / epidemiology*
  • Pregnancy Rate
  • United States / epidemiology
  • Vitamin D / administration & dosage*
  • Vitamin D / blood*
  • Vitamin D Deficiency / blood
  • Vitamin D Deficiency / diet therapy*
  • Vitamin D Deficiency / epidemiology*
  • Young Adult

Substances

  • Vitamin D

Associated data

  • ClinicalTrials.gov/NCT00642590