Mitochondrial DNA depletion induces innate immune dysfunction rescued by IFN-γ

J Allergy Clin Immunol. 2017 Nov;140(5):1461-1464.e8. doi: 10.1016/j.jaci.2017.04.048. Epub 2017 Jun 17.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA, Mitochondrial*
  • DNA-Binding Proteins / genetics
  • Escherichia coli
  • Humans
  • Immunity, Innate
  • Interferon-gamma / immunology*
  • Lipopolysaccharides
  • Mitochondrial Proteins / genetics
  • Phagocytosis
  • RNA, Small Interfering / genetics
  • Sepsis / genetics*
  • Sepsis / immunology*
  • THP-1 Cells
  • Transcription Factors / genetics

Substances

  • DNA, Mitochondrial
  • DNA-Binding Proteins
  • Lipopolysaccharides
  • Mitochondrial Proteins
  • RNA, Small Interfering
  • TFAM protein, human
  • Transcription Factors
  • Interferon-gamma