Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion

Levi B Watkin; Rabinarayan Mishra; Anna Gil; Nuray Aslan; Dario Ghersi; Katherine Luzuriaga; Liisa K Selin

doi:10.1016/j.jaci.2017.05.037

Unique influenza A cross-reactive memory CD8 T-cell receptor repertoire has a potential to protect against EBV seroconversion

J Allergy Clin Immunol. 2017 Oct;140(4):1206-1210. doi: 10.1016/j.jaci.2017.05.037. Epub 2017 Jun 16.

Authors

Levi B Watkin¹, Rabinarayan Mishra², Anna Gil², Nuray Aslan², Dario Ghersi³, Katherine Luzuriaga⁴, Liisa K Selin⁵

Affiliations

¹ Department of Pathology, University of Massachusetts Medical School, Worcester, Mass; Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, Mass.
² Department of Pathology, University of Massachusetts Medical School, Worcester, Mass.
³ School of Interdisciplinary Informatics, University of Nebraska-Omaha, Omaha, Neb.
⁴ Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, Mass; Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Mass.
⁵ Department of Pathology, University of Massachusetts Medical School, Worcester, Mass; Immunology and Microbiology Program, University of Massachusetts Medical School, Worcester, Mass. Electronic address: liisa.selin@umassmed.edu.

Abstract

Detection of unique, functionally influenza A/EBV crossreactive oligoclonal CD8 T-cell repertoires in rare individuals who remain EBV-seronegative into fourth decade of life suggests that T-cell crossreactivity dependent heterologous immunity may protect from EBV infection.

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
CD8-Positive T-Lymphocytes / immunology*
Cross Reactions
Female
Herpesvirus 4, Human / immunology*
Humans
Influenza A virus / immunology*
Male
Middle Aged
Receptors, Antigen, T-Cell / immunology*
Seroconversion

Substances

Receptors, Antigen, T-Cell

Abstract

Publication types

MeSH terms

Substances

Grants and funding