Malignant transformation of multifocal tapioca iris nevus in a child

J AAPOS. 2017 Aug;21(4):340-342. doi: 10.1016/j.jaapos.2017.06.007. Epub 2017 Jun 16.


A 31-month-old white boy was evaluated for multiple iris lesions in his left eye, initially suspected to be juvenile xanthogranuloma and later diagnosed as tapioca nevi. Four years later the tumors enlarged. There was invasion throughout the anterior segment into the angle and related secondary elevation in intraocular pressure. Fine-needle aspiration biopsy disclosed spindle-B melanoma. Treatment with custom-designed iodine-125 plaque radiotherapy resulted in tumor regression and stabilization of intraocular pressure.

Publication types

  • Case Reports

MeSH terms

  • Cell Transformation, Neoplastic / pathology
  • Child, Preschool
  • Humans
  • Iodine Radioisotopes / therapeutic use
  • Iris Neoplasms / pathology*
  • Iris Neoplasms / radiotherapy
  • Male
  • Melanoma / pathology*
  • Melanoma / radiotherapy
  • Nevus, Pigmented / pathology*
  • Radiopharmaceuticals / therapeutic use
  • Treatment Outcome


  • Iodine Radioisotopes
  • Radiopharmaceuticals