The genomic mosaicism of hybrid speciation

Sci Adv. 2017 Jun 14;3(6):e1602996. doi: 10.1126/sciadv.1602996. eCollection 2017 Jun.


Hybridization is widespread in nature and, in some instances, can result in the formation of a new hybrid species. We investigate the genetic foundation of this poorly understood process through whole-genome analysis of the hybrid Italian sparrow and its progenitors. We find overall balanced yet heterogeneous levels of contribution from each parent species throughout the hybrid genome and identify areas of novel divergence in the hybrid species exhibiting signals consistent with balancing selection. High-divergence areas are disproportionately located on the Z chromosome and overrepresented in gene networks relating to key traits separating the focal species, which are likely involved in reproductive barriers and/or species-specific adaptations. Of special interest are genes and functional groups known to affect body patterning, beak morphology, and the immune system, which are important features of diversification and fitness. We show that a combination of mosaic parental inheritance and novel divergence within the hybrid lineage has facilitated the origin and maintenance of an avian hybrid species.

Keywords: Genome evolution; Passer sparrow; genome scan; hybrid speciation; immune system; reproductive isolation; selection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosomes
  • DNA, Mitochondrial
  • Evolution, Molecular
  • Gene Ontology
  • Genetic Speciation*
  • Genetics, Population
  • Genome*
  • Genomics* / methods
  • Hybridization, Genetic*
  • Male
  • Mosaicism*
  • Phylogeny
  • Reproductive Isolation
  • Sparrows


  • DNA, Mitochondrial