Validation of a Liver Index and Its Significance for HCC Aggressiveness

J Gastrointest Cancer. 2017 Sep;48(3):262-266. doi: 10.1007/s12029-017-9971-4.


Background: We recently constructed a liver index (LI) from four liver parameters, namely: blood total bilirubin, gamma glutamyl transpeptidase (GGTP), albumin, and platelet levels (a cirrhosis surrogate). We found that the scores for the liver index related significantly to a four-parameter HCC aggressiveness index (maximum tumor diameter, multifocality, percent portal vein invasion, and blood AFP levels).

Aims: To validate the relationship of liver parameters to tumor aggressiveness parameters in a larger, different HCC dataset.

Results: We now confirm these associations in another large HCC cohort. Furthermore, this liver index showed significant trends with the individual HCC aggressiveness parameters.

Conclusions: These results provide further support for the idea that liver microenvironment, as reflected in liver function tests, may relate to HCC behavior.

Keywords: Aggressiveness index; HCC parameters; Liver function.