Systems Immunology: Just Getting Started

Nat Immunol. 2017 Jun 20;18(7):725-732. doi: 10.1038/ni.3768.


Systems-biology approaches in immunology take various forms, but here we review strategies for measuring a broad swath of immunological functions as a means of discovering previously unknown relationships and phenomena and as a powerful way of understanding the immune system as a whole. This approach has rejuvenated the field of vaccine development and has fostered hope that new ways will be found to combat infectious diseases that have proven refractory to classical approaches. Systems immunology also presents an important new strategy for understanding human immunity directly, taking advantage of the many ways the immune system of humans can be manipulated.

Publication types

  • Review

MeSH terms

  • Allergy and Immunology*
  • Humans
  • Immune System / immunology*
  • Immunologic Techniques / methods*
  • Signal Transduction / immunology
  • Systems Biology / methods*
  • Vaccines / immunology


  • Vaccines